新型杂多化合物抗禽流感病毒的实验研究

目的探讨新型杂多化合物(PTW)抗禽流感病毒的作用。方法采用细胞病变法结合MTT法检测PTW对MDCK细胞的毒性和对禽流感病毒(H5N1)的抑制作用;以H5N1感染的小鼠为实验模型,检测PTW对H5N1感染小鼠的治疗作用。结果PTW对MDCK细胞的最大无毒质量浓度为190.55 mg/L,半数致死质量浓度为909.9 mg/L;体外实验结果表明PTW对禽流感病毒半数抑制质量浓度(IC50)为13.49 mg/L,治疗指数(TI)为67.44;体内实验显示PTW对H5N1感染小鼠有明显的治疗作用,25 mg/kg剂量组对H5N1感染小鼠的肺炎抑制率达166.16%,生命延长率为28.36%。结论PTW对H5N1禽流感病毒具有较好的抑制作用。     

CD_3 McAb联合rhIL-2激活的骨髓对白血病细胞杀伤净化作用的研究

目的　探讨CD3单克隆抗体 (CD3McAb)联合重组人白细胞介素 2 (rhIL 2 )激活的骨髓对白血病细胞的杀伤及净化作用。方法　用MTT法检测激活骨髓的细胞毒作用 ;半固体集落培养法观察激活骨髓CFU GM水平和对白血病细胞的净化作用 ;采用间接荧光法测定激活骨髓的免疫标记。结果　CD3McAb与rhIL 2联合激活的骨髓对白血病细胞株K5 6 2、HL 6 0均有明显的杀伤净化作用 ,且优于rhIL 2或CD3McAb单用组 (P <0 .0 5或P <0 .0 1)。rhIL 2和 (或 )CD3McAb对激活骨髓的CFU GM水平无明显影响。CD3McAb +rhIL 2激活的骨髓 ,与活化前及rhIL 2或CD3McAb组相比 ,CD3+ 、CD8+ 、CD1 9+ 、CD2 5+ 、CD38+ 、CD56+ 细胞显著升高。结论　CD3McAb能增强rhIL 2激活的骨髓对白血病细胞的杀伤及净化作用     

大型活动中心交通需求管理策略研究

在对大型活动中心交通供需特性分析的基础之上．论证了大型活动中心需要采取交通需求管理的可行性和必要性,并分别从活动中心活动参与者以及过境出行者两个不同群体的角度提出了大型活动中心实施交通需求管理的具体目标和关键问题。并以上海市浦东三林体育中心为研究对象,对处于城市中心区的大型活动中心实施交通需求管理的策略进行了实例分析。     

一种体动换能器及其在频率自适应心脏起搏方面的应用

介绍一种利用压电效应原理，大致反映人体活动剧烈程度的体动换能器，分析了其本身性能和所测体动信号的特性。将它用于体动型频率自适应心脏起搏器的换能部分，获得了较好的实验结果。     

大型活动中心区域停车交通组织分析与设计

通过模型计算、现场调查等方法分析大型活动中心区域停车需求、路网疏散能力、停车供给能力;根据不同的停车供需结果对大型活动中心区域的停车交通组织进行优化和设计,制定最科学有效的停车交通组织方案,并以西安市曲江国际会议中心作为研究对象,对大型活动中心区域停车交通组织进行实例分析。     

支持协同设计的船舶设计过程模型研究

船舶设计过程模型是在网络环境下开展船舶并行和协同设计系统的基础.本文根据船舶设计的特点,提出了将船舶设计过程按照项目、设计任务和设计活动三个层次进行分解的方法,并给出了船舶设计过程模型形式化定义.该模型明确了设计任务间的并行、顺序和协同关系,可以直接按设计任务构成活动网络图进行规划、分析、管理等工作,使设计过程具有良好的可变更性和可控性.     

The small-sized benthic biota of the Håkon Mosby Mud Volcano (SW Barents Sea slope)

R/V POLARSTERN expedition ARK XVIII/1 in summer 2002 provided the opportunity to carry out a sampling programme to assess the activity, biomass and composition of the small-sized benthic biota (size range: bacteria to meiofauna) around the active mud-oozing and methane-seeping Håkon Mosby Mud Volcano (HMMV) on the SW Barents Sea slope, Northern North-Atlantic. A total of 11 stations, covering different areas (e.g., bacterial mat sites, and pogonophoran fields) within the crater, and sites outside the caldera were sampled using a multiple corer. Subsamples were analyzed for various biogenic compounds to estimate the flux of organic matter to the seafloor (sediment-bound chloroplastic pigments indicating phytodetritus), activities (bacterial exo-enzymatic turnover rates) and the total biomass [from bulk parameters, like phospholipid (PL) concentrations in the sediments] of the smallest sediment-inhabiting organisms (range: bacteria to meiofauna). Direct investigations of bacterial numbers and biomasses as well as on meiofauna densities and composition completed our investigations at HMMV. As expected for a comparable small deep-sea area with only minor disparity in water depth between sampling sites, our investigations revealed generally no significant differences in organic matter input from phytodetritus sedimentation between sampling sites inside and outside HMMV. Bacterial exo-enzymatic activities as well as total microbial biomass (TMB) and meiofauna densities, however, exhibited generally higher values at HMMV, compared to sites outside the mud volcano. Enhanced benthic life at HMMV is based on chemosynthetic processes, making the mud volcano a “chemosynthetic oasis” in an otherwise oligotrophic deep-sea environment. As we did not find any indication for bacterial symbioses in the meiofauna, comparably rich meiofaunal assemblages at HMMV are presumably indirectly related to a general enhanced biological production.     

原发性肾病综合征患儿T细胞亚群及其抑制性细胞活性

本文检测了37例原发性肾病综合征患儿的外周血T淋巴细胞亚群和刀豆素A诱导的抑制细胞活性水平。结果显示,肾病患儿初发时就存在抑制性T细胞数量及功能的减低,并随着激素治疗及病情的好转而恢复正常,提示本病的免疫调节失衡可能是一原发性改变,在肾病发病机理中起一定的作用。     

电力牵引工频高压电磁场对人体视—运动反应时的影响

通过对我国电力牵引达２２年区段的２７．５ｋＶ工频电场强度为１．７５－３．４６ｋＶ／ｍ，磁感应强度为０．６０－１．７５ｍＴ，人体感应电流为１０．０８－５８．４０μＡ环境下作业的１３５９名工人和无电磁场接触史的３７５名工人的视－运动反应时值进行的测验和分析。结果表明两组无明显差异。引起视－运动反应时值的延长。结果表明两组无明显差异，引起视－运动反应时值的延长，机体协调功能减退的主要原因是年龄因素的增长     

An Exploration of the Relationship between Timing and Duration of Maintenance Activities

The timing and duration of an activity episode are two important temporal aspects of activity-travel behavior. Understanding the causal relationship between these two variables would be useful in the development of activity-based travel demand modeling systems. This paper investigates the relationship between these two variables by considering two different causal structures – one structure in which time-of-day choice is determined first and influences duration and a second structure in which activity duration is determined first and affects time-of-day choice. These two structures are estimated within a discrete-continuous simultaneous equations framework employing a full-information maximum likelihood methodology that allows error covariance. The estimation is performed separately for commuter and non-commuter samples drawn from a 1996 household travel survey data set from the Tampa Bay area in Florida. The results of the model estimation effort show that the causal structure in which activity duration precedes or affects activity timing (time of day choice) performs better for the non-commuter sample. For the commuter sample, the findings were less conclusive with both causal structures offering equally good statistical measures of fit. In addition, for the commuter sample, all error correlations were found to be zero. These two findings suggest that time of day choice and activity episode duration are only loosely related for the commuter sample, possibly due to the relatively non-discretionary and inflexible work activity and travel.